The main quest is expected to have a similar playthrough time as the main quest of FO:NV.
Our current map size is slightly larger than the Commonwealth, with a smaller overall percentage covered by water. Players will start a new adventure entirely separate from the main game, with a new player character.
Cascadia is an upcoming new world-space mod for Fallout 4 set in a retro-futuristic post-apocalyptic version of Seattle and the surrounding areas.